Bergman, J., Miodownik, C., Bersudsky, Y., Sokolik, S., Lerner, P. P., Kreinin, A., ... & Lerner, V. (2013). Curcumin as an add-on to antidepressive treatment: a randomized, double-blind, placebo-controlled, pilot clinical study. Clinical neuropharmacology, 36(3), 73-77.

Kanchanatawan, B., Tangwongchai, S., Sughondhabhirom, A., Suppapitiporn, S., Hemrunrojn, S., Carvalho, A. F., & Maes, M. (2018). Add-on treatment with curcumin has antidepressive effects in Thai patients with major depression: results of a randomized double-blind placebo-controlled study. Neurotoxicity research, 33, 621-633.

Lopresti, A. L., & Drummond, P. D. (2017). Efficacy of curcumin, and a saffron/curcumin combination for the treatment of major depression: A randomised, double-blind, placebo-controlled study. Journal of affective disorders, 207, 188-196.

Lopresti, A. L., Maes, M., Maker, G. L., Hood, S. D., & Drummond, P. D. (2014). Curcumin for the treatment of major depression: a randomised, double-blind, placebo controlled study. Journal of affective disorders, 167, 368-375.

Panahi, Y., Badeli, R., Karami, G. R., & Sahebkar, A. (2015). Investigation of the efficacy of adjunctive therapy with bioavailability‐boosted curcuminoids in major depressive disorder. Phytotherapy Research, 29(1), 17-21.

Sanmukhani, J., Satodia, V., Trivedi, J., Patel, T., Tiwari, D., Panchal, B., ... & Tripathi, C. B. (2014). Efficacy and safety of curcumin in major depressive disorder: a randomized controlled trial. Phytotherapy research, 28(4), 579-585.

Yu, J. J., Pei, L. B., Zhang, Y., Wen, Z. Y., & Yang, J. L. (2015). Chronic supplementation of curcumin enhances the efficacy of antidepressants in major depressive disorder: a randomized, double-blind, placebo-controlled pilot study. Journal of clinical psychopharmacology, 35(4), 406-410.

Meta-analyser:

Al‐Karawi, D., Al Mamoori, D. A., & Tayyar, Y. (2016). The role of curcumin administration in patients with major depressive disorder: mini meta‐analysis of clinical trials. Phytotherapy Research, 30(2), 175-183.

Fusar-Poli, L., Vozza, L., Gabbiadini, A., Vanella, A., Concas, I., Tinacci, S., ... & Aguglia, E. (2020). Curcumin for depression: a meta-analysis. Critical reviews in food science and nutrition, 60(15), 2643-2653.

Ng, Q. X., Koh, S. S. H., Chan, H. W., & Ho, C. Y. X. (2017). Clinical use of curcumin in depression: a meta-analysis. Journal of the American Medical Directors Association, 18(6), 503-508.

Wang, Z., Zhang, Q., Huang, H., & Liu, Z. (2021). The efficacy and acceptability of curcumin for the treatment of depression or depressive symptoms: A systematic review and meta-analysis. Journal of

Asadi S, Gholami MS, Siassi F, Qorbani M, Sotoudeh G. Beneficial effects of nano-curcumin supplement on depression and anxiety in diabetic patients with peripheral neuropathy: a randomized, double-blind, placebo-controlled clinical trial. Phytother Res. 2020;34(4):896–903.

Cox, K. H., White, D. J., Pipingas, A., Poorun, K., & Scholey, A. (2020). Further evidence of benefits to mood and working memory from lipidated curcumin in healthy older people: a 12-week, double-blind, placebo-controlled, partial replication study. Nutrients, 12(6), 1678.

Cox KH, Pipingas A, Scholey AB. Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population. J Psychopharmacol. 2015;29(5):642–51.

Esmaily, H., Sahebkar, A., Iranshahi, M., Ganjali, S., Mohammadi, A., Ferns, G., & Ghayour-Mobarhan, M. (2015). An investigation of the effects of curcumin on anxiety and depression in obese individuals: A randomized controlled trial. Chinese journal of integrative medicine, 21, 332-338.

Fanaei H, Khayat S, Kasaeian A, Javadimehr M. Effect of cur- cumin on serum brain-derived neurotrophic factor levels in women with premenstrual syndrome: A randomized, double- blind, placebo-controlled trial. Neuropeptides. 2016;56:25–31.

Latif R, Mumtaz S, Al Sheikh MH, Chathoth S, Nasser Al Naimi S. Effects of turmeric on cardiovascular risk factors, mental health, and serum homocysteine in overweight, obese females. Altern Ther Health Med. 2021;27(Suppl 1):114–9.

Lopresti AL, Smith SJ, Rea A, Michel S. Efficacy of a curcumin extract (Curcugen) on gastrointestinal symptoms and intestinal microbiota in adults with self-reported digestive complaints: a randomised, double-blind, placebo-controlled study. BMC Com- plement Med Ther. 2021;21(1):40.

Ma T, Ma Z, Zhang X, Zhou F. Evaluation of effect of curcumin on psychological state of patients with pulmonary hypertension by magnetic resonance image under deep learning. Contrast Media Mol Imaging. 2021;2021:9935754.

Scholey, A., Cox, K., Pipingas, A., & White, D. (2020). Curcumin improves hippocampal function in healthy older adults: a three month randomised controlled trial. Proceedings of the Nutrition Society, 79(OCE2).

Sudheeran, S. P., Jacob, D., Mulakal, J. N., Nair, G. G., Maliakel, A., Maliakel, B., ... & Krishnakumar, I. M. (2016). Safety, tolerance, and enhanced efficacy of a bioavailable formulation of curcumin with fenugreek dietary fiber on occupational stress: A randomized, double-blind, placebo-controlled pilot study. Journal of clinical psychopharmacology, 36(3), 236-243.

Cox KH, Pipingas A, Scholey AB. Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population. J Psychopharmacol. 2015;29(5):642–51.

Khanna, A., Das S, S., Kannan, R., Swick, A. G., Matthewman, C., Maliakel, B., ... & Krishnakumar, I. M. (2022). The effects of oral administration of curcumin–galactomannan complex on brain waves are consistent with brain penetration: a randomized, double-blinded, placebo-controlled pilot study. Nutritional Neuroscience, 25(6), 1240-1249.

Sudheeran, S. P., Jacob, D., Mulakal, J. N., Nair, G. G., Maliakel, A., Maliakel, B., ... & Krishnakumar, I. M. (2016). Safety, tolerance, and enhanced efficacy of a bioavailable formulation of curcumin with fenugreek dietary fiber on occupational stress: A randomized, double-blind, placebo-controlled pilot study. Journal of clinical psychopharmacology, 36(3), 236-243.

Yu, J. J., Pei, L. B., Zhang, Y., Wen, Z. Y., & Yang, J. L. (2015). Chronic supplementation of curcumin enhances the efficacy of antidepressants in major depressive disorder: a randomized, double-blind, placebo-controlled pilot study. Journal of clinical psychopharmacology, 35(4), 406-410.

Asadi S, Gholami MS, Siassi F, Qorbani M, Sotoudeh G. Beneficial effects of nano-curcumin supplement on depression and anxiety in diabetic patients with peripheral neuropathy: a randomized, double-blind, placebo-controlled clinical trial. Phytother Res. 2020;34(4):896–903.

Latif R, Mumtaz S, Al Sheikh MH, Chathoth S, Nasser Al Naimi S. Effects of turmeric on cardiovascular risk factors, mental health, and serum homocysteine in overweight, obese females. Altern Ther Health Med. 2021;27(Suppl 1):114–9.

Lopresti AL, Smith SJ, Rea A, Michel S. Efficacy of a curcumin extract (Curcugen) on gastrointestinal symptoms and intestinal microbiota in adults with self-reported digestive complaints: a randomised, double-blind, placebo-controlled study. BMC Com- plement Med Ther. 2021;21(1):40.

Agarwal, K. A., Tripathi, C. D., Agarwal, B. B., & Saluja, S. (2011). Efficacy of turmeric (curcumin) in pain and postoperative fatigue after laparoscopic cholecystectomy: a double-blind, randomized placebo-controlled study. Surgical endoscopy, 25, 3805-3810.

Ahmadi, S., Mehrabi, Z., Zare, M., Ghadir, S., & Masoumi, S. J. (2023). Efficacy of Nanocurcumin as an Add-On Treatment for Patients Hospitalized with COVID-19: A Double-Blind, Randomized Clinical Trial. International Journal of Clinical Practice, 2023.

Cox, K. H., White, D. J., Pipingas, A., Poorun, K., & Scholey, A. (2020). Further evidence of benefits to mood and working memory from lipidated curcumin in healthy older people: a 12-week, double-blind, placebo-controlled, partial replication study. Nutrients, 12(6), 1678.

Cox KH, Pipingas A, Scholey AB. Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population. J Psychopharmacol. 2015;29(5):642–51.

Khanna, A., Das S, S., Kannan, R., Swick, A. G., Matthewman, C., Maliakel, B., ... & Krishnakumar, I. M. (2022). The effects of oral administration of curcumin–galactomannan complex on brain waves are consistent with brain penetration: a randomized, double-blinded, placebo-controlled pilot study. Nutritional Neuroscience, 25(6), 1240-1249.

Kuszewski JC, Howe PRC, Wong RHX. An exploratory analy- sis of changes in mental wellbeing following curcumin and fish oil supplementation in middle-aged and older adults. Nutrients. 2020;12(10):2902.

Scholey, A., Cox, K., Pipingas, A., & White, D. (2020). Curcumin improves hippocampal function in healthy older adults: a three month randomised controlled trial. Proceedings of the Nutrition Society, 79(OCE2).

Sudheeran, S. P., Jacob, D., Mulakal, J. N., Nair, G. G., Maliakel, A., Maliakel, B., ... & Krishnakumar, I. M. (2016). Safety, tolerance, and enhanced efficacy of a bioavailable formulation of curcumin with fenugreek dietary fiber on occupational stress: A randomized, double-blind, placebo-controlled pilot study. Journal of clinical psychopharmacology, 36(3), 236-243.

Cox, K. H., White, D. J., Pipingas, A., Poorun, K., & Scholey, A. (2020). Further evidence of benefits to mood and working memory from lipidated curcumin in healthy older people: a 12-week, double-blind, placebo-controlled, partial replication study. Nutrients, 12(6), 1678.

Dost, F. S., Kaya, D., Ontan, M. S., Erken, N., Bulut, E. A., Aydin, A. E., & Isik, A. T. (2021). Theracurmin supplementation may be a therapeutic option for older patients with Alzheimer’s disease: a 6-month retrospective follow-up study. Current Alzheimer Research, 18(14), 1087-1092.

Kuszewski JC, Howe PRC, Wong RHX. An exploratory analysis of changes in mental wellbeing following curcumin and fish oil supplementation in middle-aged and older adults. Nutrients. 2020;12(10):2902.

Rainey-Smith, S. R., Brown, B. M., Sohrabi, H. R., Shah, T., Goozee, K. G., Gupta, V. B., & Martins, R. N. (2016). Curcumin and cognition: a randomised, placebo-controlled, double-blind study of community-dwelling older adults. British Journal of Nutrition, 115(12), 2106-2113.

Scholey, A., Cox, K., Pipingas, A., & White, D. (2020). Curcumin improves hippocampal function in healthy older adults: a three month randomised controlled trial. Proceedings of the Nutrition Society, 79(OCE2).

Small, G. W., Siddarth, P., Li, Z., Miller, K. J., Ercoli, L., Emerson, N. D., ... & Barrio, J. R. (2018). Memory and brain amyloid and tau effects of a bioavailable form of curcumin in non-demented adults: a double-blind, placebo-controlled 18-month trial. The American Journal of Geriatric Psychiatry, 26(3), 266-277.

Hosseininasab, M., Zarghami, M., Mazhari, S., Salehifar, E., Moosazadeh, M., Fariborzifar, A., ... & Hendouei, N. (2021). Nanocurcumin as an add-on to antipsychotic drugs for treatment of negative symptoms in patients with chronic schizophrenia: a randomized, double-blind, placebo-controlled study. Journal of Clinical Psychopharmacology, 41(1), 25-30.

Lamanna-Rama, N., Romero-Miguel, D., Desco, M., & Soto-Montenegro, M. L. (2022). An update on the exploratory use of curcumin in neuropsychiatric disorders. Antioxidants, 11(2), 353.

Miodownik, C., Lerner, V., Kudkaeva, N., Lerner, P. P., Pashinian, A., Bersudsky, Y., ... & Bergman, J. (2019). Curcumin as add-on to antipsychotic treatment in patients with chronic schizophrenia: a randomized, double-blind, placebo-controlled study. Clinical neuropharmacology, 42(4), 117-122.

Agarwal, K. A., Tripathi, C. D., Agarwal, B. B., & Saluja, S. (2011). Efficacy of turmeric (curcumin) in pain and postoperative fatigue after laparoscopic cholecystectomy: a double-blind, randomized placebo-controlled study. Surgical endoscopy, 25, 3805-3810.

Belcaro, G., Cesarone, M. R., Dugall, M., Pellegrini, L., Ledda, A., Grossi, M. G., ... & Appendino, G. (2010). Efficacy and safety of Meriva®, a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients. Altern Med Rev, 15(4), 337-344.

Belcaro, G., Cesarone, M. R., Dugall, M., Pellegrini, L., Ledda, A., Grossi, M. G., ... & Appendino, G. (2010). Product-evaluation registry of Meriva®, a curcumin-phosphatidylcholine complex, for the complementary management of osteoarthritis. Panminerva Med, 52(2 Suppl 1), 55-62.

Francesco, D. P., Giuliana, R., Eleonora, A. D. M., Giovanni, A., Federico, F., & Stefano, T. (2013). Comparative evaluation of the pain-relieving properties of a lecithinized formulation of curcumin (Meriva®), nimesulide, and acetaminophen. Journal of pain research, 201-205.

Lamanna-Rama, N., Romero-Miguel, D., Desco, M., & Soto-Montenegro, M. L. (2022). An update on the exploratory use of curcumin in neuropsychiatric disorders. Antioxidants, 11(2), 353.

Lopresti, A. L., Hood, S. D., & Drummond, P. D. (2012). Multiple antidepressant potential modes of action of curcumin: a review of its anti-inflammatory, monoaminergic, antioxidant, immune-modulating and neuroprotective effects. Journal of psychopharmacology, 26(12), 1512-1524.

Lopresti, A. L., Smith, S. J., & Drummond, P. D. (2022). Modulation of the hypothalamic–pituitary–adrenal (HPA) axis by plants and phytonutrients: A systematic review of human trials. Nutritional Neuroscience, 25(8), 1704-1730.

Lopresti, A. L. (2022). Potential role of curcumin for the treatment of major depressive disorder. CNS drugs, 36(2), 123-141.

Ramaholimihaso, T., Bouazzaoui, F., & Kaladjian, A. (2020). Curcumin in depression: potential mechanisms of action and current evidence—a narrative review. Frontiers in psychiatry, 11, 572533.

Examine.com. (2023, July 6). Research breakdown on curcumin. Examine. https://examine.com/supplements/curcumin/research/

El NE, Bagdas D, Toma W, Al SH, Brodzik A, Alkhlaif Y, et al. Curcumin acts as a positive allosteric modulator of a 7 -nicotinic acetylcholine receptors and reverses nociception in mouse models of inflammatory pain. J Pharmacol Exp Ther. 2018;365(1):190–200.

Naqvi, F., Saleem, S., Naqvi, F., Batool, Z., Sadir, S., Tabassum, S., ... & Haider, S. (2019). Curcumin lessens unpredictable chronic mild stress-induced depression and memory deficits by modulating oxidative stress and cholinergic activity. Pak J Pharm Sci, 32(4), 1893-1900.

Sarlak, Z., Oryan, S., & Moghaddasi, M. (2015). Interaction between the antioxidant activity of curcumin and cholinergic system on memory retention in adult male Wistar rats. Iranian journal of basic medical sciences, 18(4), 398.

Srivastava, P., Yadav, R. S., Chandravanshi, L. P., Shukla, R. K., Dhuriya, Y. K., Chauhan, L. K., ... & Khanna, V. K. (2014). Unraveling the mechanism of neuroprotection of curcumin in arsenic induced cholinergic dysfunctions in rats. Toxicology and Applied Pharmacology, 279(3), 428-440.

Voulgaropoulou, S. D., Van Amelsvoort, T. A. M. J., Prickaerts, J., & Vingerhoets, C. (2019). The effect of curcumin on cognition in Alzheimer’s disease and healthy aging: A systematic review of pre-clinical and clinical studies. Brain research, 1725, 146476.

Yadav, R. S., Chandravanshi, L. P., Shukla, R. K., Sankhwar, M. L., Ansari, R. W., Shukla, P. K., ... & Khanna, V. K. (2011). Neuroprotective efficacy of curcumin in arsenic induced cholinergic dysfunctions in rats. Neurotoxicology, 32(6), 760-768

Hegde, M., Girisa, S., BharathwajChetty, B., Vishwa, R., & Kunnumakkara, A. B. (2023). Curcumin Formulations for Better Bioavailability: What We Learned from Clinical Trials Thus Far?. ACS omega, 8(12), 10713-10746.

Hegde, M., Girisa, S., BharathwajChetty, B., Vishwa, R., & Kunnumakkara, A. B. (2023). Curcumin Formulations for Better Bioavailability: What We Learned from Clinical Trials Thus Far?. ACS omega, 8(12), 10713-10746.

Lopresti, A. L. (2022). Potential role of curcumin for the treatment of major depressive disorder. CNS drugs, 36(2), 123-141.

Examine.com. (2023, July 6). Research breakdown on curcumin. Examine. https://examine.com/supplements/curcumin/research/

Hatcher, H., Planalp, R., Cho, J., Torti, F. M., & Torti, S. V. (2008). Curcumin: from ancient medicine to current clinical trials. Cellular and molecular life sciences, 65, 1631-1652.