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FORSKNINGSLITTERATUR PÅ LAVENDEL

  • Subjektiv Følelse av Stress​
    Akhgarjand, C., Asoudeh, F., Bagheri, A., Kalantar, Z., Vahabi, Z., Shab‐bidar, S., ... & Djafarian, K. (2022). Does Ashwagandha supplementation have a beneficial effect on the management of anxiety and stress? A systematic review and meta‐analysis of randomized controlled trials. Phytotherapy Research, 36(11), 4115-4124. DOI: 10.1002/ptr.7598 Auddy B., Hazra J., Mitra A., Abedon B., Ghosal S. (2008). A standardized Withania somnifera extract significantly reduces stress-related parameters in chronically stressed humans: A double-blind, randomized, placebo-controlled study. Journal of the American Nutraceutical Association, 11, 50–56. Lenke til artikkel Chai, S. C., Li, I., Pacanowski, C., & Brewer, B. (2020). Effects of Four-Week Supplementation of Ashwagandha and B-Vitamins on Mood and Stress Relief. Current Developments in Nutrition, 4(Supplement_2), 1195-1195. DOI: 10.1093/cdn/nzaa057_011 Chandrasekhar, K., Kapoor, J., & Anishetty, S. (2012). A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian journal of psychological medicine, 34(3), 255-262. DOI: 10.4103/0253-7176.106022 Chengappa, K. R., Brar, J. S., Gannon, J. M., & Schlicht, P. J. (2018). Adjunctive use of a standardized extract of Withania somnifera (Ashwagandha) to treat symptom exacerbation in schizophrenia: a randomized, double-blind, placebo-controlled study. The Journal of Clinical Psychiatry, 79(5), 22496. DOI: 10.4088/jcp.17m11826 Choudhary, D., Bhattacharyya, S., & Joshi, . (2017). Body weight management in adults under chronic stress through treatment with ashwagandha root extract: a double-blind, randomized, placebo-controlled trial. Journal of evidence-based complementary & alternative medicine, 22(1), 96-106. DOI: 10.1177/2156587216641830 Gopukumar, K., Thanawala, S., Somepalli, V., Rao, T. S., Thamatam, V. B., & Chauhan, S. (2021). Efficacy and Safety of Ashwagandha Root Extract on Cognitive Functions in Healthy, Stressed Adults: A Randomized, Double-Blind, Placebo-Controlled Study. Evidence-Based Complementary and Alternative Medicine, 2021. DOI:10.1155/2021/8254344 Li, I. (2020). Stress & Anxiety Improvements with Ashwagandha and B-Vitamins. University of Delaware. Lenke til artikkel Li, I., Pacanowski, C., Cao, L., & Chai, S. C. (2020). Evaluation of Self-Reported Stress Reduction from Ashwagandha and B Vitamin Supplementation Using Ecological Momentary Assessment (EMA). Current Developments in Nutrition, 4(Supplement_2), 1219-1219. DOI: 10.1093/cdn/nzaa057_035 Lopresti, A. L., Smith, S. J., Malvi, H., & Kodgule, R. (2019). An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study. Medicine, 98(37). DOI: 10.1097/MD.0000000000017186 Majeed, M., Nagabhushanam, K., & Mundkur, L. (2023). A standardized Ashwagandha root extract alleviates stress, anxiety, and improves quality of life in healthy adults by modulating stress hormones: Results from a randomized, double-blind, placebo-controlled study. Medicine, 102(41), e35521. Remenapp, A., Coyle, K., Orange, T., Lynch, T., Hooper, D., Hooper, S., Conway, K., & Hausenblas, H. A. (2022). Efficacy of Withania somnifera supplementation on adult’s cognition and mood. Journal of Ayurveda and Integrative Medicine, 13(2), 100510. DOI: 10.1016/j.jaim.2021.08.003 Salve, J., Pate, S., Debnath, K., & Langade, D. (2019). Adaptogenic and anxiolytic effects of ashwagandha root extract in healthy adults: a double-blind, randomized, placebo-controlled clinical study. Cureus, 11(12). DOI: 10.7759/cureus.6466
  • Motstandsdyktighet
    Auddy B., Hazra J., Mitra A., Abedon B., Ghosal S. (2008). A standardized Withania somnifera extract significantly reduces stress-related parameters in chronically stressed humans: A double-blind, randomized, placebo-controlled study. Journal of the American Nutraceutical Association, 11, 50–56. Lenke til artikkel Baker, C., Kirby, J. B., O'Connor, J., Lindsay, K. G., Hutchins, A., & Harris, M. (2022). The Perceived Impact of Ashwagandha on Stress, Sleep Quality, Energy, and Mental Clarity for College Students: Qualitative Analysis of a Double-Blind Randomized Control Trial. Journal of Medicinal Food. DOI: 10.1089/jmf.2022.0042 Biswal, B. M., Sulaiman, S. A., Ismail, H. C., Zakaria, H., & Musa, K. I. (2013). Effect of Withania somnifera (Ashwagandha) on the development of chemotherapy-induced fatigue and quality of life in breast cancer patients. Integrative cancer therapies, 12(4), 312-322. DOI: 10.1177/1534735412464551 Bonilla, D. A., Moreno, Y., Gho, C., Petro, J. L., Odriozola-Martínez, A., & Kreider, R. B. (2021). Effects of Ashwagandha (Withania somnifera) on physical performance: systematic review and bayesian meta-analysis. Journal of Functional Morphology and Kinesiology, 6(1), 20. DOI: 10.3390/jfmk6010020 Cooley, K., Szczurko, O., Perri, D., Mills, E. J., Bernhardt, B., Zhou, Q., & Seely, D. (2009). Naturopathic care for anxiety: a randomized controlled trial ISRCTN78958974. PLoS One, 4(8), e6628. DOI: 10.1371/journal.pone.0006628 Mandlik, D. S., & Namdeo, A. G. (2021). Pharmacological evaluation of Ashwagandha highlighting its healthcare claims, safety, and toxicity aspects. Journal of Dietary Supplements, 18(2), 183-226. DOI: 10.1080/19390211.2020.1741484 Pérez-Gómez, J., Villafaina, S., Adsuar, J. C., Merellano-Navarro, E., & Collado-Mateo, D. (2020). Effects of Ashwagandha (Withania somnifera) on VO2max: a systematic review and meta-analysis. Nutrients, 12(4), 1119. DOI: 10.3390/nu12041119 Tiwari, S., Gupta, S. K., & Pathak, A. K. (2021). A double-blind, randomized, placebo-controlled trial on the effect of Ashwagandha (Withania somnifera dunal.) root extract in improving cardiorespiratory endurance and recovery in healthy athletic adults. Journal of ethnopharmacology, 272, 113929. DOI: 10.1016/j.jep.2021.113929 Wankhede, S., Langade, D., Joshi, K., Sinha, S. R., & Bhattacharyya, S. (2015). Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial. Journal of the International Society of Sports Nutrition, 12(1), 1-11. DOI: 10.1186/s12970-015-0104-9
  • Velvære og Livskvalitet
    Auddy B., Hazra J., Mitra A., Abedon B., Ghosal S. (2008). A standardized Withania somnifera extract significantly reduces stress-related parameters in chronically stressed humans: A double-blind, randomized, placebo-controlled study. Journal of the American Nutraceutical Association, 11, 50–56. Lenke til artikkel Biswal, B. M., Sulaiman, S. A., Ismail, H. C., Zakaria, H., & Musa, K. I. (2013). Effect of Withania somnifera (Ashwagandha) on the development of chemotherapy-induced fatigue and quality of life in breast cancer patients. Integrative cancer therapies, 12(4), 312-322. DOI: 10.1177/1534735412464551 Chai, S. C., Li, I., Pacanowski, C., & Brewer, B. (2020). Effects of Four-Week Supplementation of Ashwagandha and B-Vitamins on Mood and Stress Relief. Current Developments in Nutrition, 4(Supplement_2), 1195-1195. DOI: 10.1093/cdn/nzaa057_011 Chandrasekhar, K., Kapoor, J., & Anishetty, S. (2012). A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian journal of psychological medicine, 34(3), 255-262. DOI: 10.4103/0253-7176.106022 Chengappa, K. R., Bowie, C. R., Schlicht, P. J., Fleet, D., Brar, J. S., & Jindal, R. (2013). Randomized placebo-controlled adjunctive study of an extract of Withania somnifera for cognitive dysfunction in bipolar disorder. The Journal of clinical psychiatry, 74(11), 16816. DOI: 10.4088/jcp.13m08413 Choudhary, B., Shetty, A., & Langade, D. G. (2015). Efficacy of Ashwagandha (Withania somnifera [L.] Dunal) in improving cardiorespiratory endurance in healthy athletic adults. Ayu, 36(1), 63. DOI: 10.4103/0974-8520.169002 Choudhary, D., Bhattacharyya, S., & Joshi, K. (2017). Body weight management in adults under chronic stress through treatment with ashwagandha root extract: a double-blind, randomized, placebo-controlled trial. Journal of evidence-based complementary & alternative medicine, 22(1), 96-106. DOI: 10.1177/2156587216641830 Cooley, K., Szczurko, O., Perri, D., Mills, E. J., Bernhardt, B., Zhou, Q., & Seely, D. (2009). Naturopathic care for anxiety: a randomized controlled trial ISRCTN78958974. PLoS One, 4(8), e6628. DOI: 10.1371/journal.pone.0006628 Deshpande, A., Irani, N., Balkrishnan, R., & Benny, I. R. (2020). A randomized, double blind, placebo controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults. Sleep medicine, 72, 28-36. DOI: 10.1016/j.sleep.2020.03.012 ​ Gopukumar, K., Thanawala, S., Somepalli, V., Rao, T. S., Thamatam, V. B., & Chauhan, S. (2021). Efficacy and Safety of Ashwagandha Root Extract on Cognitive Functions in Healthy, Stressed Adults: A Randomized, Double-Blind, Placebo-Controlled Study. Evidence-Based Complementary and Alternative Medicine, 2021. DOI:10.1155/2021/8254344 Kelgane, S. B., Salve, J., Sampara, P., & Debnath, K. (2020). Efficacy and tolerability of Ashwagandha root extract in the elderly for improvement of general well-being and sleep: a prospective, randomized, double-blind, placebo-controlled study. Cureus, 12(2). DOI: 10.7759/cureus.7083 Li, I. (2020). Stress & Anxiety Improvements with Ashwagandha and B-Vitamins. University of Delaware. Lenke til artikkel Li, I., Pacanowski, C., Cao, L., & Chai, S. C. (2020). Evaluation of Self-Reported Stress Reduction from Ashwagandha and B Vitamin Supplementation Using Ecological Momentary Assessment (EMA). Current Developments in Nutrition, 4(Supplement_2), 1219-1219. DOI: 10.1093/cdn/nzaa057_035 Langade, D., Thakare, V., Kanchi, S., & Kelgane, S. (2021). Clinical evaluation of the pharmacological impact of ashwagandha root extract on sleep in healthy volunteers and insomnia patients: A double-blind, randomized, parallel-group, placebo-controlled study. Journal of Ethnopharmacology, 264, 113276. DOI: 10.1016/j.jep.2020.113276 Majeed, M., Nagabhushanam, K., & Mundkur, L. (2023). A standardized Ashwagandha root extract alleviates stress, anxiety, and improves quality of life in healthy adults by modulating stress hormones: Results from a randomized, double-blind, placebo-controlled study. Medicine, 102(41), e35521.
  • Mental helse
    Andrade, C., Aswath, A., Chaturvedi, S. K., Srinivasa, M., & Raguram, R. (2000). A double-blind, placebo-controlled evaluation of the anxiolytic efficacy ff an ethanolic extract of withania somnifera. Indian journal of psychiatry, 42(3), 295. PMCID: PMC2958355 Auddy B., Hazra J., Mitra A., Abedon B., Ghosal S. (2008). A standardized Withania somnifera extract significantly reduces stress-related parameters in chronically stressed humans: A double-blind, randomized, placebo-controlled study. Journal of the American Nutraceutical Association, 11, 50–56. Lenke til artikkel Chai, S. C., Li, I., Pacanowski, C., & Brewer, B. (2020). Effects of Four-Week Supplementation of Ashwagandha and B-Vitamins on Mood and Stress Relief. Current Developments in Nutrition, 4(Supplement_2), 1195-1195. DOI: 10.1093/cdn/nzaa057_011 Chandrasekhar, K., Kapoor, J., & Anishetty, S. (2012). A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian journal of psychological medicine, 34(3), 255-262. DOI: 10.4103/0253-7176.106022 Chengappa, K. R., Brar, J. S., Gannon, J. M., & Schlicht, P. J. (2018). Adjunctive use of a standardized extract of Withania somnifera (Ashwagandha) to treat symptom exacerbation in schizophrenia: a randomized, double-blind, placebo-controlled study. The Journal of Clinical Psychiatry, 79(5), 22496. DOI: 10.4088/jcp.17m11826 Choudhary, D., Bhattacharyya, S., & Joshi, K. (2017). Body weight management in adults under chronic stress through treatment with ashwagandha root extract: a double-blind, randomized, placebo-controlled trial. Journal of evidence-based complementary & alternative medicine, 22(1), 96-106. DOI: 10.1177/2156587216641830 Cooley, K., Szczurko, O., Perri, D., Mills, E. J., Bernhardt, B., Zhou, Q., & Seely, D. (2009). Naturopathic care for anxiety: a randomized controlled trial ISRCTN78958974. PLoS One, 4(8), e6628. DOI: 10.1371/journal.pone.0006628 Fuladi, S., Emami, S. A., Mohammadpour, A. H., Karimani, A., Manteghi, A. A., & Sahebkar, A. (2021). Assessment of the efficacy of Withania somnifera root extract in patients with generalized anxiety disorder: a randomized double-blind placebo-controlled trial. Current Reviews in Clinical and Experimental Pharmacology Formerly Current Clinical Pharmacology, 16(2), 191-196. DOI: 10.2174/1574884715666200413120413 Gannon, J. M., Brar, J., Rai, A., & Chengappa, K. R. (2019). Effects of a standardized extract of Withania somnifera (Ashwagandha) on depression and anxiety symptoms in persons with schizophrenia participating in a randomized, placebo-controlled clinical trial. Ann Clin Psychiatry, 31(2), 123-9. Lenke til artikkel. Jahanbakhsh, S. P., Manteghi, A. A., Emami, S. A., Mahyari, S., Gholampour, B., Mohammadpour, A. H., & Sahebkar, A. (2016). Evaluation of the efficacy of Withania somnifera (Ashwagandha) root extract in patients with obsessive-compulsive disorder: A randomized double-blind placebo-controlled trial. Complementary Therapies in Medicine, 27, 25-29. DOI: 10.1016/j.ctim.2016.03.018 Khyati, S., & Anup, B. (2013). A randomized double blind placebo controlled study of ashwagandha on generalized anxiety disorder. Int Ayurvedic Med J, 1, 1-7. Lenke til artikkel. Langade, D., Kanchi, S., Salve, J., Debnath, K., & Ambegaokar, D. (2019). Efficacy and safety of Ashwagandha (Withania somnifera) root extract in insomnia and anxiety: a double-blind, randomized, placebo-controlled study. Cureus, 11(9). DOI: 10.7759/cureus.5797 Langade, D., Thakare, V., Kanchi, S., & Kelgane, S. (2021). Clinical evaluation of the pharmacological impact of ashwagandha root extract on sleep in healthy volunteers and insomnia patients: A double-blind, randomized, parallel-group, placebo-controlled study. Journal of Ethnopharmacology, 264, 113276. DOI: 10.1016/j.jep.2020.113276 Li, I. (2020). Stress & Anxiety Improvements with Ashwagandha and B-Vitamins. University of Delaware. Lenke til artikkel Lopresti, A. L., Smith, S. J., Malvi, H., & Kodgule, R. (2019). An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study. Medicine, 98(37). DOI: 10.1097/MD.0000000000017186 Majeed, M., Nagabhushanam, K., & Mundkur, L. (2023). A standardized Ashwagandha root extract alleviates stress, anxiety, and improves quality of life in healthy adults by modulating stress hormones: Results from a randomized, double-blind, placebo-controlled study. Medicine, 102(41), e35521. ​ Remenapp, A., Coyle, K., Orange, T., Lynch, T., Hooper, D., Hooper, S., Conway, K., & Hausenblas, H. A. (2022). Efficacy of Withania somnifera supplementation on adult’s cognition and mood. Journal of Ayurveda and Integrative Medicine, 13(2), 100510. DOI: 10.1016/j.jaim.2021.08.003 ​ Salve, J., Pate, S., Debnath, K., & Langade, D. (2019). Adaptogenic and anxiolytic effects of ashwagandha root extract in healthy adults: a double-blind, randomized, placebo-controlled clinical study. Cureus, 11(12). DOI: 10.7759/cureus.6466
  • Kognitive Funksjoner
    Auddy B., Hazra J., Mitra A., Abedon B., Ghosal S. (2008). A standardized Withania somnifera extract significantly reduces stress-related parameters in chronically stressed humans: A double-blind, randomized, placebo-controlled study. Journal of the American Nutraceutical Association, 11, 50–56. Lenke til artikkel ​ Chengappa, K. R., Bowie, C. R., Schlicht, P. J., Fleet, D., Brar, J. S., & Jindal, R. (2013). Randomized placebo-controlled adjunctive study of an extract of Withania somnifera for cognitive dysfunction in bipolar disorder. The Journal of clinical psychiatry, 74(11), 16816. DOI: 10.4088/jcp.13m08413 ​ Choudhary, D., Bhattacharyya, S., & Bose, S. (2017). Efficacy and safety of Ashwagandha (Withania somnifera (L.) Dunal) root extract in improving memory and cognitive functions. Journal of dietary supplements, 14(6), 599-612. DOI: 10.1080/19390211.2017.1284970 ​ Gopukumar, K., Thanawala, S., Somepalli, V., Rao, T. S., Thamatam, V. B., & Chauhan, S. (2021). Efficacy and Safety of Ashwagandha Root Extract on Cognitive Functions in Healthy, Stressed Adults: A Randomized, Double-Blind, Placebo-Controlled Study. Evidence-Based Complementary and Alternative Medicine, 2021. DOI:10.1155/2021/8254344 ​ Li, I., Pacanowski, C., Cao, L., & Chai, S. C. (2020). Evaluation of Self-Reported Stress Reduction from Ashwagandha and B Vitamin Supplementation Using Ecological Momentary Assessment (EMA). Current Developments in Nutrition, 4(Supplement_2), 1219-1219. DOI: 10.1093/cdn/nzaa057_035 ​ Ng, Q. X., Loke, W., Foo, N. X., Tan, W. J., Chan, H. W., Lim, D. Y., & Yeo, W. S. (2020). A systematic review of the clinical use of Withania somnifera (Ashwagandha) to ameliorate cognitive dysfunction. Phytotherapy Research, 34(3), 583-590. DOI: 10.1002/ptr.6552 ​ Pingali, U., Pilli, R., & Fatima, N. (2014). Effect of standardized aqueous extract of Withania somnifera on tests of cognitive and psychomotor performance in healthy human participants. Pharmacognosy research, 6(1), 12. DOI: 10.4103/0974-8490.122912 ​ Remenapp, A., Coyle, K., Orange, T., Lynch, T., Hooper, D., Hooper, S., Conway, K., & Hausenblas, H. A. (2022). Efficacy of Withania somnifera supplementation on adult’s cognition and mood. Journal of Ayurveda and Integrative Medicine, 13(2), 100510. DOI: 10.1016/j.jaim.2021.08.003 Kelgane, S. B., Salve, J., Sampara, P., & Debnath, K. (2020). Efficacy and tolerability of Ashwagandha root extract in the elderly for improvement of general well-being and sleep: a prospective, randomized, double-blind, placebo-controlled study. Cureus, 12(2). DOI: 10.7759/cureus.7083 Langade, D., Thakare, V., Kanchi, S., & Kelgane, S. (2021). Clinical evaluation of the pharmacological impact of ashwagandha root extract on sleep in healthy volunteers and insomnia patients: A double-blind, randomized, parallel-group, placebo-controlled study. Journal of Ethnopharmacology, 264, 113276. DOI: 10.1016/j.jep.2020.113276 ​ Xing, D., Yoo, C., Gonzalez, D., Jenkins, V., Nottingham, K., Dickerson, B., ... & Kreider, R. B. (2022). Effects of Acute Ashwagandha Ingestion on Cognitive Function. International Journal of Environmental Research and Public Health, 19(19), 11852. DOI: 10.3390/ijerph191911852 ​
  • Nevrotransmittersystemer
    Serotonin Systemet ​ Bhatnagar, M., Sharma, D., & Salvi, M. (2009). Neuroprotective effects of Withania somnifera dunal.: a possible mechanism. Neurochemical Research, 34(11), 1975-1983. DOI: 10.1007/s11064-009-9987-7 ​ Kaurav, B. P., Wanjari, M. M., Chandekar, A., Chauhan, N. S., & Upmanyu, N. (2012). Influence of Withania somnifera on obsessive compulsive disorder in mice. Asian Pacific Journal of Tropical Medicine, 5(5), 380-384. DOI: 10.1016/s1995-7645(12)60063-7 ​ Tripathi, A. K., Dey, S., Singh, R. H., & Dey, P. K. (1998). Alterations in the sensitivity of 5th receptor subtypes following chronic Asvagandha treatment in rats. Ancient Science of Life, 17(3), 169. PMCID: PMC3331105 ​ Speers, A. B., Cabey, K. A., Soumyanath, A., & Wright, K. M. (2021). Effects of Withania somnifera (Ashwagandha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Current Neuropharmacology, 19(9), 1468. DOI: 10.2174/1570159X19666210712151556 ​ Glycin (Glutamat) Systemet ​ Bhatnagar, M., Sharma, D., & Salvi, M. (2009). Neuroprotective effects of Withania somnifera dunal.: a possible mechanism. Neurochemical Research, 34(11), 1975-1983. DOI: 10.1007/s11064-009-9987-7 ​ Bhattarai, J. P., Park, S. J., & Han, S. K. (2013). Potentiation of NMDA receptors by Withania somnifera on hippocampal CA1 pyramidal neurons. The American Journal of Chinese Medicine, 41(03), 503-513. DOI: 10.1142/S0192415X13500365 ​ Grunze, H., Langosch, J., von Loewenich, C., & Walden, J. (2000). Modulation of neural cell membrane conductance by the herbal anxiolytic and antiepileptic drug aswal. Neuropsychobiology, 42(Suppl. 1), 28-32. DOI: 10.1159/000054849 ​ Soman, S., Anju, T. R., Jayanarayanan, S., Antony, S., & Paulose, C. S. (2013). Impaired motor learning attributed to altered AMPA receptor function in the cerebellum of rats with temporal lobe epilepsy: ameliorating effects of Withania somnifera and withanolide A. Epilepsy & Behavior, 27(3), 484-491. DOI: 10.1016/j.yebeh.2013.01.007 ​ Soman, S., Korah, P. K., Jayanarayanan, S., Mathew, J., & Paulose, C. S. (2012). Oxidative stress induced NMDA receptor alteration leads to spatial memory deficits in temporal lobe epilepsy: ameliorative effects of Withania somnifera and Withanolide A. Neurochemical research, 37(9), 1915-1927. DOI: 10.1007/s11064-012-0810-5 ​ GABA Systemet ​ Bhattarai, J. P., Ah Park, S., & Han, S. K. (2010). The methanolic extract of Withania somnifera ACTS on GABAA receptors in GnRH neurons in mice. Phytotherapy Research, 24(8), 1147-1150. DOI: 10.1002/ptr.3088 ​ Kulkarni, S. K., Akula, K. K., & Dhir, A. (2008). Effect of Withania somnifera Dunal root extract against pentylenetetrazol seizure threshold in mice: possible involvement of GABAergic system. PMID: 18697606 ​ Kumar, A., & Kalonia, H. (2008). Effect of Withania somnifera on sleep-wake cycle in sleep-disturbed rats: Possible GABAergic mechanism. Indian journal of pharmaceutical sciences, 70(6), 806. DOI: 10.4103/0250-474X.49130 ​ Mehta, A. K., Binkley, P., Gandhi, S. S., & Ticku, M. K. (1991). Pharmacological effects of Withania somnifera root extract on GABAA receptor complex. The Indian Journal of Medical Research, 94, 312-315. PMID: 1660034 ​ Speers, A. B., Cabey, K. A., Soumyanath, A., & Wright, K. M. (2021). Effects of Withania somnifera (Ashwagandha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Current Neuropharmacology, 19(9), 1468. DOI: 10.2174/1570159X19666210712151556 ​ Acetylkolin Systemet ​ Bhatnagar, M., Sharma, D., & Salvi, M. (2009). Neuroprotective effects of Withania somnifera dunal.: a possible mechanism. Neurochemical Research, 34(11), 1975-1983. DOI: 10.1007/s11064-009-9987-7 ​ Choudhary, M. I., Yousuf, S., Nawaz, S. A., & Ahmed, S. (2004). Cholinesterase inhibiting withanolides from Withania somnifera. Chemical and pharmaceutical bulletin, 52(11), 1358-1361. DOI: 10.1248/cpb.52.1358 ​ Grover, A., Shandilya, A., Agrawal, V., Bisaria, V. S., & Sundar, D. (2012). Computational evidence to inhibition of human acetyl cholinesterase by withanolide a for Alzheimer treatment. Journal of Biomolecular Structure and Dynamics, 29(4), 651-662. DOI: 10.1080/07391102.2012.10507408 ​ Schliebs, R., Liebmann, A., Bhattacharya, S. K., Kumar, A., Ghosal, S., & Bigl, V. (1997). Systemic administration of defined extracts from Withania somnifera (Indian Ginseng) and Shilajit differentially affects cholinergic but not glutamatergic and GABAergic markers in rat brain. Neurochemistry International, 30(2), 181-190. DOI: 10.1016/s0197-0186(96)00025-3 ​ Speers, A. B., Cabey, K. A., Soumyanath, A., & Wright, K. M. (2021). Effects of Withania somnifera (Ashwagandha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Current Neuropharmacology, 19(9), 1468. DOI: 10.2174/1570159X19666210712151556 ​ Yadav, C. S., Kumar, V., Suke, S. G., Ahmed, R. S., Mediratta, P. K., & Banerjee, B. D. (2010). Propoxur-induced acetylcholine esterase inhibition and impairment of cognitive function: attenuation by Withania somnifera. PMID: 20521626 ​ Katekolamin systemet (Adrenalin/Epinefrin og Dopamin) ​ Shah, P. C., Trivedi, N. A., Bhatt, J. D., & Hemavathi, K. G. (2006). Effect of Withania somnifera on forced swimming test induced immobility in mice and its interaction with various drugs. Indian journal of physiology and pharmacology, 50(4), 409. PMID: 17402272 ​ Priyanka, G., Anil Kumar, B., Lakshman, M., Manvitha, V., & Kala Kumar, B. (2020). Adaptogenic and immunomodulatory activity of Ashwagandha root extract: An experimental study in an equine model. Frontiers in veterinary science, 7, 541112. DOI: 10.3389/fvets.2020.541112 ​ RajaSankar, S., Manivasagam, T., Sankar, V., Prakash, S., Muthusamy, R., Krishnamurti, A., & Surendran, S. (2009). Withania somnifera root extract improves catecholamines and physiological abnormalities seen in a Parkinson's disease model mouse. Journal of Ethnopharmacology, 125(3), 369-373. DOI: 10.1016/j.jep.2009.08.003
  • Stresshormoner (HPA-aksen)
    Auddy B., Hazra J., Mitra A., Abedon B., Ghosal S. (2008). A standardized Withania somnifera extract significantly reduces stress-related parameters in chronically stressed humans: A double-blind, randomized, placebo-controlled study. Journal of the American Nutraceutical Association, 11, 50–56. Lenke til artikkel Baitharu, I., Jain, V., Deep, S. N., Hota, K. B., Hota, S. K., Prasad, D., & Ilavazhagan, G. (2013). Withania somnifera root extract ameliorates hypobaric hypoxia induced memory impairment in rats. Journal of ethnopharmacology, 145(2), 431-441. DOI: 10.1016/j.jep.2012.10.063 Bhatnagar, M., Sharma, D., & Salvi, M. (2009). Neuroprotective effects of Withania somnifera dunal.: a possible mechanism. Neurochemical Research, 34(11), 1975-1983. DOI: 10.1007/s11064-009-9987-7 ​ Chandrasekhar, K., Kapoor, J., & Anishetty, S. (2012). A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian journal of psychological medicine, 34(3), 255-262. DOI: 10.4103/0253-7176.106022 ​ Choudhary, D., Bhattacharyya, S., & Joshi, K. (2017). Body weight management in adults under chronic stress through treatment with ashwagandha root extract: a double-blind, randomized, placebo-controlled trial. Journal of evidence-based complementary & alternative medicine, 22(1), 96-106. DOI: 10.1177/2156587216641830 ​ Gopukumar, K., Thanawala, S., Somepalli, V., Rao, T. S., Thamatam, V. B., & Chauhan, S. (2021). Efficacy and Safety of Ashwagandha Root Extract on Cognitive Functions in Healthy, Stressed Adults: A Randomized, Double-Blind, Placebo-Controlled Study. Evidence-Based Complementary and Alternative Medicine, 2021. DOI:10.1155/2021/8254344 ​ Kalani, A., Bahtiyar, G., & Sacerdote, A. (2012). Ashwagandha root in the treatment of non-classical adrenal hyperplasia. Case Reports, 2012, bcr2012006989. DOI: 10.1136/bcr-2012-006989 ​ Lopresti, A. L., Smith, S. J., Malvi, H., & Kodgule, R. (2019). An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study. Medicine, 98(37). DOI: 10.1097/MD.0000000000017186 Majeed, M., Nagabhushanam, K., & Mundkur, L. (2023). A standardized Ashwagandha root extract alleviates stress, anxiety, and improves quality of life in healthy adults by modulating stress hormones: Results from a randomized, double-blind, placebo-controlled study. Medicine, 102(41), e35521. ​ Mahdi, A. A., Shukla, K. K., Ahmad, M. K., Rajender, S., Shankhwar, S. N., Singh, V., & Dalela, D. (2011). Withania somnifera improves semen quality in stress-related male fertility. Evidence-Based Complementary and Alternative Medicine, 2011. DOI: 10.1093/ecam/nep138 ​ Pingali, U., Pilli, R., & Fatima, N. (2013). Effect of Withania somnifera extract on mental stress induced changes in hemodynamic properties and arterial wave reflections in healthy subjects. Current Topics in Nutraceuticals Research, 11(4), 151. Lenke til artikkel. ​ Remenapp, A., Coyle, K., Orange, T., Lynch, T., Hooper, D., Hooper, S., Conway, K., & Hausenblas, H. A. (2022). Efficacy of Withania somnifera supplementation on adult’s cognition and mood. Journal of Ayurveda and Integrative Medicine, 13(2), 100510. DOI: 10.1016/j.jaim.2021.08.003 ​ Salve, J., Pate, S., Debnath, K., & Langade, D. (2019). Adaptogenic and anxiolytic effects of ashwagandha root extract in healthy adults: a double-blind, randomized, placebo-controlled clinical study. Cureus, 11(12). DOI: 10.7759/cureus.6466 ​ Singh, B., Chandan, B. K., & Gupta, D. K. (2003). Adaptogenic activity of a novel withanolide‐free aqueous fraction from the roots of Withania somnifera Dun.(Part II). Phytotherapy Research, 17(5), 531-536. DOI: 10.1002/ptr.1189 ​ Speers, A. B., Cabey, K. A., Soumyanath, A., & Wright, K. M. (2021). Effects of Withania somnifera (Ashwagandha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Current Neuropharmacology, 19(9), 1468. DOI: 10.2174/1570159X19666210712151556
  • Immunregulering og Inflammasjon
    Auddy B., Hazra J., Mitra A., Abedon B., Ghosal S. (2008). A standardized Withania somnifera extract significantly reduces stress-related parameters in chronically stressed humans: A double-blind, randomized, placebo-controlled study. Journal of the American Nutraceutical Association, 11, 50–56. Lenke til artikkel Gupta, M., & Kaur, G. (2018). Withania somnifera as a potential anxiolytic and anti-inflammatory candidate against systemic lipopolysaccharide-induced neuroinflammation. Neuromolecular medicine, 20(3), 343-362. DOI: 10.1007/s12017-018-8497-7 ​ Mandlik, D. S., & Namdeo, A. G. (2021). Pharmacological evaluation of Ashwagandha highlighting its healthcare claims, safety, and toxicity aspects. Journal of Dietary Supplements, 18(2), 183-226. DOI: 10.1080/19390211.2020.1741484 ​ Priyanka, G., Anil Kumar, B., Lakshman, M., Manvitha, V., & Kala Kumar, B. (2020). Adaptogenic and immunomodulatory activity of Ashwagandha root extract: An experimental study in an equine model. Frontiers in veterinary science, 7, 541112. DOI: 10.3389/fvets.2020.541112 ​ Kaur, T., Singh, H., Mishra, R., Manchanda, S., Gupta, M., Saini, V., ... & Kaur, G. (2017). Withania somnifera as a potential anxiolytic and immunomodulatory agent in acute sleep deprived female Wistar rats. Molecular and cellular biochemistry, 427(1), 91-101. DOI: 10.1007/s11010-016-2900-1 ​ Khan, B., Ahmad, S. F., Bani, S., Kaul, A., Suri, K. A., Satti, N. K., ... & Qazi, G. N. (2006). Augmentation and proliferation of T lymphocytes and Th-1 cytokines by Withania somnifera in stressed mice. International immunopharmacology, 6(9), 1394-1403. DOI: 10.1016/j.intimp.2006.04.001 ​ Kour, K., Pandey, A., Suri, K. A., Satti, N. K., Gupta, K. K., & Bani, S. (2009). Restoration of stress-induced altered T cell function and corresponding cytokines patterns by Withanolide A. International immunopharmacology, 9(10), 1137-1144. DOI: 10.1016/j.intimp.2009.05.011 ​ Paul, S., Chakraborty, S., Anand, U., Dey, S., Nandy, S., Ghorai, M., ... & Dey, A. (2021). Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects. Biomedicine & Pharmacotherapy, 143, 112175. DOI: 10.1016/j.biopha.2021.112175 ​ ​Tharakan, A., Shukla, H., Benny, I. R., Tharakan, M., George, L., & Koshy, S. (2021). Immunomodulatory Effect of Withania somnifera (Ashwagandha) Extract—A Randomized, Double-Blind, Placebo Controlled Trial with an Open Label Extension on Healthy Participants. Journal of clinical medicine, 10(16), 3644. DOI: 10.3390/jcm10163644
  • Beskyttende Effekt på Cellenivå
    Mandlik, D. S., & Namdeo, A. G. (2021). Pharmacological evaluation of Ashwagandha highlighting its healthcare claims, safety, and toxicity aspects. Journal of Dietary Supplements, 18(2), 183-226. DOI: 10.1080/19390211.2020.1741484 ​ Mukherjee, P. K., Banerjee, S., Biswas, S., Das, B., Kar, A., & Katiyar, C. K. (2021). Withania somnifera (L.) Dunal-Modern perspectives of an ancient Rasayana from Ayurveda. Journal of Ethnopharmacology, 264, 113157. DOI: 10.1016/j.jep.2020.113157 ​ Paul, S., Chakraborty, S., Anand, U., Dey, S., Nandy, S., Ghorai, M., ... & Dey, A. (2021). Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects. Biomedicine & Pharmacotherapy, 143, 112175. DOI: 10.1016/j.biopha.2021.112175 ​ Soman, S., Anju, T. R., Jayanarayanan, S., Antony, S., & Paulose, C. S. (2013). Impaired motor learning attributed to altered AMPA receptor function in the cerebellum of rats with temporal lobe epilepsy: ameliorating effects of Withania somnifera and withanolide A. Epilepsy & Behavior, 27(3), 484-491. DOI: 10.1016/j.yebeh.2013.01.007 ​ Soman, S., Korah, P. K., Jayanarayanan, S., Mathew, J., & Paulose, C. S. (2012). Oxidative stress induced NMDA receptor alteration leads to spatial memory deficits in temporal lobe epilepsy: ameliorative effects of Withania somnifera and Withanolide A. Neurochemical research, 37(9), 1915-1927. DOI: 10.1007/s11064-012-0810-5 ​ Speers, A. B., Cabey, K. A., Soumyanath, A., & Wright, K. M. (2021). Effects of Withania somnifera (Ashwagandha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Current Neuropharmacology, 19(9), 1468. DOI: 10.2174/1570159X19666210712151556 ​ Tohda, C., Komatsu, K., & Kuboyama, T. (2005). Scientific basis for the anti-dementia drugs of constituents from Ashwagandha (Withania somnifera). J Tad Med, 22, 176-182. Lenke til artikkel. ​ Zahiruddin, S., Basist, P., Parveen, A., Parveen, R., Khan, W., & Ahmad, S. (2020). Ashwagandha in brain disorders: A review of recent developments. Journal of ethnopharmacology, 257, 112876. DOI: 10.1016/j.jep.2020.112876 ​
  • Bioaktive Plantemolekyler
    Mandlik, D. S., & Namdeo, A. G. (2021). Pharmacological evaluation of Ashwagandha highlighting its healthcare claims, safety, and toxicity aspects. Journal of Dietary Supplements, 18(2), 183-226. DOI: 10.1080/19390211.2020.1741484 ​ Paul, S., Chakraborty, S., Anand, U., Dey, S., Nandy, S., Ghorai, M., ... & Dey, A. (2021). Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects. Biomedicine & Pharmacotherapy, 143, 112175. DOI: 10.1016/j.biopha.2021.112175
  • Fravær av Bivirkninger
    Chengappa, K. R., Brar, J. S., Gannon, J. M., & Schlicht, P. J. (2018). Adjunctive use of a standardized extract of Withania somnifera (Ashwagandha) to treat symptom exacerbation in schizophrenia: a randomized, double-blind, placebo-controlled study. The Journal of Clinical Psychiatry, 79(5), 22496. DOI: 10.4088/jcp.17m11826 Gopukumar, K., Thanawala, S., Somepalli, V., Rao, T. S., Thamatam, V. B., & Chauhan, S. (2021). Efficacy and Safety of Ashwagandha Root Extract on Cognitive Functions in Healthy, Stressed Adults: A Randomized, Double-Blind, Placebo-Controlled Study. Evidence-Based Complementary and Alternative Medicine, 2021. DOI:10.1155/2021/8254344 ​ Mandlik, D. S., & Namdeo, A. G. (2021). Pharmacological evaluation of Ashwagandha highlighting its healthcare claims, safety, and toxicity aspects. Journal of Dietary Supplements, 18(2), 183-226. DOI: 10.1080/19390211.2020.1741484 ​ Verma, N., Gupta, S. K., Tiwari, S., & Mishra, A. K. (2021). Safety of ashwagandha root extract: a randomized, placebo-controlled, study in healthy volunteers. Complementary therapies in medicine, 57, 102642. DOI: 10.1016/j.ctim.2020.102642
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